PAGOCLONE CAS#133737-32-3

1.GABA receptor modulation: Pagolone selectively modulates GABA (γ-aminobutyric acid) receptors and helps maintain the balance of GABAergic signaling.

2.Potential benefit for stuttering: By influencing GABA(A) receptor activity, Pagolone has shown potential in alleviating stuttering symptoms.

3.Novel cyclopyrrolone scaffold: As a new cyclopyrrolone-class compound, Pagolone exhibits pharmacological features that differ from those of conventional GABA-related agents.

4.Partial GABA(A) receptor agonist: Pagolone works as a partial agonist at GABA(A) receptors, allowing targeted regulation of inhibitory neurotransmission.

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Product Description of Pagoclone CAS#133737-32-3

Pagoclone acts as a selective regulator for GABA (Gamma‑aminobutyric acid) receptors and exhibits potential for stuttering mitigation. Belonging to a new cyclopyrrolone chemical class, it exerts partial agonistic effects on GABA(A) receptors, which accounts for its distinctive pharmacological characteristics.

PAGOCLONE Chemical Properties

Boiling point	582.1±50.0 °C(Predicted)
density	1.273±0.06 g/cm3(Predicted)
pka	1.62±0.30(Predicted)
InChI	InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3
InChIKey	HIUPRQPBWVEQJJ-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2

PAGOCLONE CAS#133737-32-3

Product Application of Pagoclone CAS#133737-32-3

Pagoclone serves as a selective modulator for gamma‑aminobutyric acid (GABA) receptors and possesses the capacity to ease stuttering manifestations. This innovative cyclopyrrolone‑type compound exerts partial agonistic activity at GABA(A) receptors.

PAGOCLONE CAS#133737-32-3