Product Details
Product Description of Collagenase CAS#9001-12-1
Collagenase, also known as clostridial peptidase, is a proteolytic enzyme obtained via fermentation of Clostridium histolyticum.
Medical-grade collagenase is purified from the culture broth of Clostridium histolyticum ATCC 21000 and shows strong catalytic activity toward peptide bonds containing the Gly–Pro sequence.
By cleaving native collagen molecules, it creates favorable conditions for the action of other proteases, giving it a unique ability to hydrolyze both natural and denatured collagen.
This medical enzyme can effectively digest natural and denatured collagen, acts strongly on necrotic tissue, and promotes the formation of granulation tissue and the growth of epithelial cells.
It does not act on globulin or fibrin, thus protecting normal blood vessels and muscle tissue. It is widely used for debridement, eschar removal, and the treatment of chronic skin ulcers, bedsores, and second and third degree burns.
Collagenase Chemical Properties
| Storage temp | -20°C |
| Solubility | Soluble in aqueous buffers. |
| Form | powder |
| Color | light brown |
| PH | 7 |
| Merck | 2481 |
| InChIKey | YRQNKMKHABXEJZ-UVQQGXFZSA-N |
| CAS DataBase Reference | 9001/12/1 |
| EPA Substance Registry System | Collagenase (9001-12-1) |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42 |
| Safety Statements | 22-24-26-36/37 |
| WGK Germany | 1 |
| F | 10-21 |
| HS Code | 3507907000 |
Product Application of Collagenase CAS#9001-12-1
Role in Wound Healing and Scar ManagementCollagen plays a vital role in wound repair and scar formation. As a key component of elastic and connective tissues, it supports cell growth, differentiation, tissue development, and fibroblast proliferation. It also promotes capillary regeneration, induces chemotaxis of monocytes and fibroblasts, and nourishes granulation tissue. Research has confirmed that collagen is effective in treating various skin ulcers, accelerating epithelialization in both superficial and deep wounds, and enhancing granulation tissue formation.
Importance in Bone Structure and StrengthCollagen accounts for 70–80% of the organic matrix in bone. During osteogenesis, collagen fibers form the initial structural framework, earning collagen the description of “bone within bone.” These fibers provide tensile strength, flexibility, and elasticity to bone, much like steel reinforcement in concrete. Inadequate collagen content weakens bone structure and greatly increases the risk of fractures.
Support Function in Breast StructureCollagen is critical for maintaining breast shape and firmness. The breast is mainly composed of connective and adipose tissue, and its contour relies heavily on the strength of connective tissue. As the major structural protein, collagen forms a network with proteoglycans that delivers mechanical support, helping to sustain breast shape and firmness.
Protective and Elastic Function in SkinCollagen is often referred to as the “skeleton of the skin.” It forms the main structure of the dermis, which is about 2 mm thick and includes the papillary, subpapillary, and reticular layers. Collagen makes up roughly 70% of the dermis, alongside elastin. Acting as a natural protective layer, it allows the skin to move freely while retaining elasticity, firmness, and barrier function.
