Product Details
Pimaricin, also referred to as natamycin (INN), is a natural antifungal substance acquired via fermentation of Streptomyces natalensis. Classified as a macrolide polyene antifungal agent, it is commonly applied for the treatment of fungal keratitis, an ocular infectious disease. In medical applications, it exerts potent effects against extensive fungal infections induced by Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. In the food industry, it is widely adopted as a natural preservative to prevent fungal contamination. Its mechanism of action relies on binding to ergosterol in the fungal plasma membrane, disrupting ergosterol‑dependent vacuole fusion and membrane fusion to inhibit fungal proliferation. Furthermore, it blocks the transport of amino acids and glucose by interfering with membrane transport proteins.
| Product Name: | Natamycin |
| Synonyms: | NataMycin, A 5283, Delvolan, Delvocid, Myprozine, Natacyn, Natafucin, PiMafucin, PiMafugin, A5263, CL 12625, E235;Natamycin(FermentionProcess);(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25- carboxylic acid;NATAMYCIN;PIMAFUCIN;PIMARICIN;PIMARICIN, STREPTOMYCES CHATTANOOGENSIS;antibiotica-5283 |
| CAS: | 7681-93-8 |
| MF: | C33H47NO13 |
| MW: | 665.73 |
| EINECS: | 231-683-5 |
| Product Categories: | Food additives;Food & Feed ADDITIVES;Antifungal (Topical);Intermediates & Fine Chemicals;Pharmaceuticals;ERGOSTAT;antibiotic;raw materials;Food additive;7681-93-8 |
| Mol File: | 7681-93-8.mol |
Natamycin Chemical Properties
| Melting point | 2000C (dec) |
| Alpha | D20 +278° (c = 1 in CH3COOH) |
| Boiling point | 952℃ |
| Density | 1.0 g/mL at 20 °C(lit.) |
| Bulk density | 200kg/m3 |
| Refractive index | 1.5960 (estimate) |
| Fp | >110°(230°F) |
| Storage temp | Keep in dark place,Inert atmosphere,2-8°C |
| Solubility | Soluble in DMSO |
| Form | Aqueous suspension |
| Pka | PKa 4.6(50% aq. MeOEtOH) (Uncertain);8.35 (Uncertain) |
| Color | Cream colored |
| Water Solubility | 0.41g/L(21 ºC) |
| Sensitive | Light Sensitive |
| Merck | 13,6453 |
| BRN | 1614878 |
| Stability | Light sensitive |
| InChIKey | NCXMLFZGDNKEPB-FFPOYIOWSA-N |
| LogP | 0.880 (est) |
| EPA Substance Registry System | 6,11,28-Trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, 22-[(3-amino-3,6-dideoxy-.beta.-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-, (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)- (7681-93-8) |
Pimaricin serves as a surface preservative coating for Italian cheeses to inhibit the growth of molds and yeasts. It is tasteless, odorless and colorless, and will not penetrate into the interior of cheese. Highly effective against almost all molds and yeasts, it leaves bacteria unaffected, thereby ensuring the natural ripening process and flavor formation of cheese. It can be applied by dipping, spraying or blending into cheese coatings, with the typical dosage ranging from 300 to 2000 ppm.
