Product Details
Product Description of 4-Dimethylaminopyridine CAS#1122-58-3
4-Dimethylaminopyridine (DMAP) is a highly efficient nucleophilic acylation catalyst. The electron-donating dimethylamino group resonates with the pyridine ring, strongly activating the nitrogen atom of the ring for nucleophilic substitution. This significantly promotes the acylation and esterification of alcohols, amines and acids, including substrates with high steric hindrance or low reactivity. Its catalytic activity is approximately 10⁴–10⁶ times higher than that of pyridine. Acyl transfer is a fundamental reaction in both natural processes and organic synthesis, and chiral DMAP is widely used as a catalyst for asymmetric acyl transfer.
4-Dimethylaminopyridine Chemical Properties
| Melting point | 112 °C |
| Boiling point | 162 °C |
| density | 0.906 g/mL at 25 °C |
| vapor pressure | 0.169 hPa at 20 °C |
| refractive index | n20/D 1.431 |
| Fp | 110 °C |
| storage temp. | Store below +30°C. |
| solubility | methanol: 50 mg/mL, clear |
| form | prilled |
| pka | pKa (20°): 9.7 |
| color | off-white to yellow |
| Odor | characteristic odor |
| PH Range | 9.7 (10% aq soln) |
| PH | 11 (60g/l, H2O, 20℃) |
| Water Solubility | 76 g/L (25 ºC) |
| Merck | 143389 |
| BRN | 110354 |
| Stability: | Stable. Incompatible with acids, oxidizing agents. |
| LogP | 1.34 at 25℃ |
| CAS DataBase Reference | 1122-58-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Pyridinamine, N,N-dimethyl-(1122-58-3) |
| EPA Substance Registry System | 4-(Dimethylamino)pyridine (1122-58-3) |
Safety Information
| Hazard Codes | T,C,T+,Xn,F |
| Risk Statements | 25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19 |
| Safety Statements | 36/37/39-45-28A-26-28-36/37-53-27-22-16 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | US8400000 |
| Autoignition Temperature | 420 °C |
| Hazard Note | Toxic/Corrosive |
| TSCA | T |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29333999 |
| Toxicity | LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg |
Product Application of 4-Dimethylaminopyridine CAS#1122-58-3
It is used in water softening and the preparation of high-purity water, as well as in the refining of radioactive elements. It is also applied in iodine extraction from seaweed, antibiotic purification, and the treatment of industrial wastewater.
