Products Description of Meglumine CAS#6284-40-8
Selecting an appropriate counter-ion is crucial for enhancing the solubility and bioavailability of pharmaceutical compounds. Meglumine (N-methyl-D-glucosamine) is a commonly used counter-ion that effectively improves drug solubility, solving the problem of poor solubility of some pharmaceutical compounds and ensuring the full play of drug efficacy. It is an amino sugar derived from sorbitol, with a pKa of approximately 9.6, which can form stable combinations with various pharmaceutical ingredients, providing reliable support for the formulation of pharmaceutical products and laying a solid foundation for the practical application of drugs in clinical practice.
Meglumine Chemical Properties
| Melting point | 129-131.5 °C (lit.) |
| Alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| Density | 1.2669 (rough estimate) |
| Refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| Storage temp | 2-8°C |
| Solubility | H2O: 0.1 g/mL, clear, colorless |
| Form | Crystalline Powder |
| Pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| Color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| Optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 146,078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| LogP | -3.370 (est) |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | Meglumine (6284-40-8) |
Safety Information
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 2003/10/23 |
| Autoignition Temperature | ~662 °F |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
