Product Details
Neomycin sulfate falls within the aminoglycoside class of antibiotics and also functions as a calcium‑channel protein inhibitor. It attaches to prokaryotic ribosomes to block protein translation, exhibiting activity against both Gram‑positive and Gram‑negative bacteria. Moreover, it inhibits phospholipase C (PLC) through binding to inositol phospholipids and depresses the activity of phosphatidylcholine‑PLD. It can trigger calcium ion mobilization as well as PLA2 activation within human platelets. This compound is capable of stopping DNA degradation brought on by DNase I. Its main application lies in the prophylaxis and treatment of bacterial skin infections, and it shows no efficacy against fungi or viruses.
Chemical Properties
| Melting point | >187°C (dec.) |
| Alpha | D20 +54° (c = 2 in H2O) |
| Bulk density | 640kg/m3 |
| Refractive index | 56 ° (C=10, H2O) |
| Fp | 56℃ |
| Storage temp | 2-8°C |
| Solubility | H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
| Form | powder |
| Color | white to slightly yellow |
| PH | 5.0-7.5 (50g/l, H2O, 20℃) |
| Biological source | Streptomyces sp |
| Water Solubility | Soluble in water |
| Merck | 14,6454 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | OIXVKQDWLFHVGR-VTSVPHRWSA-N |
| LogP | -3.655 (est) |
| CAS DataBase Reference | 1405-10-3(CAS DataBase Reference) |
| EPA Substance Registry System | Neomycin sulfate (1405-10-3) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 42/43-22 |
| Safety Statements | 23-36/37-45-22-36-24/25 |
| WGK Germany | 3 |
| RTECS | QP4375000 |
| F | 8 |
| TSCA | Yes |
| HS Code | 29419000 |
| Toxicity | LD50 oral in mouse: > 8gm |
